Proteins are large, complex molecules that carry out the tasks of life. They direct our bodies' activities, organize our thoughts, and defend us against infection, keeping us healthy. But in their ...

Structural mass spectrometry has emerged as a powerful approach to elucidate the three‐dimensional conformations of proteins and their complexes under near‐physiological conditions. In particular, ...

This Clinical Chemistry and Laboratory Medicine review examines a central challenge in precision medicine: whether medical ...

Proteomics arrived on the biotech scene a decade ago, promising a new discovery route to disease markers. Much more complex than genomics, it represents the industrial-scale analysis of the vast array ...

Those hoping to uncover new science may feel disheartened if they struggle with inadequate tools and doubt that more capable tools are within reach. Until recently, such was the case in proteomics.

Just like workers need the right environment to efficiently perform their tasks, proteins require placement within specific cellular compartments to function properly. Therefore, understanding the ...

Historically, these factors have made the identification of proteins incredibly challenging. The advent of mass spectrometry (MS) and MS-based proteomics helped to change that. 2 MS is an analytical ...

A screening technique commonly used in drug discovery can yield important details about the actions of molecular ‘glues’ in protein interactions. Molecular glues are emerging as powerful therapeutic ...

Daily administration of MGCD265 to patients with solid tumors in a dose-escalation phase I study (study 265-101). Background: To evaluate SELDI as a potential technique for predicting response to ...

New study reveals how mass spectrometry can be used to determine the mechanisms used by molecular glues to stick to their targets. Molecular glues are a continually expanding area of medicinal ...